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To review extant data on the efficacy and safety of anxiolytic medications (benzodiazepines, buspirone, and other serotonin 1A agonists), adrenergic agents (beta-blockers and alpha 2-adrenergic agonists clonidine and guanfacine), and the opiate antagonist naltrexone that have been used to treat various psychopathologies in children and adolescents.

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In another embodiment, the polymorphic form is present with naltrexone benzyl alcohol solvate, and in amount of at least about 88% or less than about 65% by weight of total crystalline naltrexone or, alternatively, is not present in an amount of about 67.

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We recommend repeating the Naltrexone pellet implant every 2 months over a period of six to twelve months.

In those patients who complied with medication and attended appointments, naltrexone over a period of 3 months helped patients reduce their alcohol consumption, reduced their perceptions of craving and improved their global recovery as assessed by their physician, and was accompanied by a reduction in serum markers of alcohol consumption.

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