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Do not take MIRAPEX for a condition for which it was not prescribed.

Third, the incidence of augmentation was greatest with the higher pramipexole dose.

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Research implicates a potential role of the dopaminergic system in the pathophysiology of bipolar disorder.

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In addition to increasing adherence, a review of 5 PD studies using sustained-release levodopa formulations (requiring at least twice-daily dosing) for PD therapy found that the less frequent dosing schedule was associated with greater patient preference and quality-of-life scores.

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The over-arching premise is that drugs which target the detrimental "cytokine cycle" that drives neuroinflammation will delay AD progression and improve the quality of life for patients.

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Food does not affect the extent of pramipexole absorption, although the time of maximum plasma concentration (T max) is increased by about 1 hour when the drug is taken with a meal.

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The precise mechanism of action of MIRAPEX tablets as a treatment for RLS is unknown.

Pramipexole is processed by the kidney.

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Alongside this, the main observation promoting the 5-HT theory was that administration of a MAOI in conjunction with tryptophan (precursor of 5-HT) elevated mood in control patients and potentiated the antidepressant effect of MAOI.

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By restoring normal function of this channel, we can reduce the histopathological features of amyloid and tau aggregation, preserve normal synaptic structure and function, and prevent the memory impairments that characterize this disease.

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We have taken an innovative approach to mitigating cognitive loss in AD: ameliorating the chronic, non-resolving inflammation that is characteristic of all forms of AD.

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If you are taking pramipexole to treat Parkinson's disease, take the missed dose as soon as you remember it.

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The Short Form 36 (SF-36) Health Survey (Change From Baseline) (Excluding the Physical Functioning Subscale(PF)).

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MIRAPEX tablets contain pramipexole, a nonergot dopamine agonist.

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Doses should not be increased more frequently than every 5 to 7 days.

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Your doctor may adjust your dose as needed.

Despite these concerns, pramipexole does have a role in the treatment of PD in all stages of the illness and may arguably be the treatment of choice in early disease.

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