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Such pharmacophores have been the start point for a wide range of lead generation and optimization programs using techniques such as Biol.

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Multiple classes of NPs such as macrolides, opioids, steroids, and β-lactams used to treat a variety of conditions such as cancers, infections, inflammation are exemplified.

In the period since our last review, other authors prominent in the natural product community have also published excellent reviews on natural products as drugs, and these, together with the review by Butler et al.

SPP-100, which became the drug aliskiren ( 10) and gained FDA approval in March 2007 and EMA approval in August 2007.

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